The present disclosure relates to a synbiotic composition comprising the probiotic Lactobacillus rhamnosus HNOO1 and a carbohydrate-based prebiotic such as fructooligosaccharides, galactooligosaccharides, human milk oligosaccharides, or combinations thereof, and the use of the composition for the prevention and/or treatment of allergic disease. In one embodiment, the symbiotic composition comprising the probiotic and prebiotic may be included in a nutritional composition or infant formula.