FULLER, WILLIAM DEAN,PHIASIVONGSA, PASIT,SEHL, LOUIS, C,LAIDIG, GUY, J
申请号：
NZ58481408
公开号：
NZ584814A
申请日:
2008.10.03
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a crystalline compound having the structure as represented by formula (II). The compound can be prepared in crystalline form by preparing a solution of a compound of formula (II) in an organic solvent (such as acetonitrile, methanol, ethanol, ethyl acetate, isopropyl acetate, methyl ethyl ketone or acetone) (ii) bringing the solution to supersaturation to cause formation of crystals (which may for example comprise the addition of an anti-solvent such as water) and (iii) isolating the crystals. Further disclosed are crystalline salts of the compound of Formula (II), and particularly preferable crystalline salts are the citrate, tartrate, trifiuoroacetate, methanesulfonate, toluenesulfonate, chloride, and bromide salts. A medicament which comprises a crystalline compound of formula (II) for treating a disease or condition selected from cancer, autoimmune disease, graft or transplant-related condition, neurodegenerative disease, fibrotic-associated condition, ischemic-related conditions, infection (viral, parasitic or prokaryotic) and diseases associated with bone loss is further disclosed.
