A method of seating a fluid reservoir in a housing of a fluid infusion device is presented here. The method is performed prior to establishing an outgoing fluid flow path from the fluid reservoir. The method begins by detecting insertion of the fluid reservoir into the housing of the fluid infusion device. In response to detecting the insertion, the method determines whether the fluid reservoir is in need of depressurization. When the fluid reservoir is in need of depressurization, the drive motor assembly of the fluid infusion device is rewound to depressurize the fluid reservoir. After depressurizing the fluid reservoir, an equalization state for the fluid reservoir is achieved. After achieving the equilibrium state, the drive motor assembly is advanced to obtain an initial seated state for the fluid reservoir.
