GAVIN THURSTON,NICHOLAS J. PAPADOPOULOS,JOEL H. MARTIN,ERIC SMITH,IRENE NOGUERA-TROISE
申请号:
PT07862940
公开号:
PT2115003E
申请日:
2007.12.14
申请国别(地区):
PT
年份:
2012
代理人:
摘要:
An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti-hDII4 antibody or antibody fragment binds hDll4 with an affinity of ‰¤ 500 pM, as measured by surface plasmon resonance.