PALESE, PETER,GARCIA-SASTRE, ADOLFO,MUSTER, THOMAS
申请号：
CA2334895
公开号：
CA2334895C
申请日:
1999.06.11
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates, in general, to attenuated negative-strand RNAviruses having an impaired ability to antagonize the cellular interferon (IFN)response, and the use of such attenuated viruses in vaccine and pharmaceuticalformulations. The invention also relates to the development and use of IFN-deficient systems for selection of such attenuated viruses. In particular, theinvention relates to attenuated influenza viruses having modifications to theNS1 gene that diminish or eliminate the ability of the NS1 gene product toantagonize the cellular IFN response. The mutant viruses replicate in vivo butdemonstrate reduced pathogenicity, and therefore are well suited for livevirus vaccines, and pharmaceutical formulations.
