A method of treating biological tissue with proton beam, comprising the steps of: irradiating a proton beam to a biological tissue, which contains a reactant, and wherein said reactant includes a first composite and a second composite allowing said first composite to react with at least one proton from said proton beam and then emit at least one neutron inside said biological tissue allowing said second composite to react with at least one said neutron to release at least one α particle or γ rays, and said α particle or said γ rays to affect said biological tissue一種利用質子束處理生物組織的方法,包括下列步驟:將一質子束照射一包含一反應物之一生物組織,其中該反應物包含一第一複合物及一第二複合物;該第一複合物與該質子束中一個以上的質子反應後於該生物組織內釋出一個以上個中子;該第二複合物與該中子反應後於該生物組織內釋出一個以上α粒子或一γ射線,該α粒子或該γ射線對該生物組織產生作用。201、202、203、204‧‧‧步驟