PURPOSE: A composition containing a Cudrania tricuspidata stem extract is provided to effectively treat inflammation or prevent skin lesion due to atopic dermatitis. CONSTITUTION: A composition for preventing and treating atopic dermatitis contains a Cudrania tricuspidata stem extract as an active ingredient. The extract is prepared by extracting Cudrania tricuspidata with water, low carbon number alcohol, or a mixture thereof. The low carbon number alcohol is ethanol or methanol. The extract contains quercetin, kaempferol, and an ingredient which is detected at absorbance 370nm and 7.8min as main ingredients. A health functional food for preventing and treating atopic dermatitis contains the extract as an active ingredient.본 발명은 꾸지뽕나무(Cudrania tricuspidata) 추출물을 유효성분으로 함유하는 조성물에 관한 것으로, 보다 구체적으로는 꾸지뽕나무(Cudrania tricuspidata) 줄기 추출물을 함유하는, 아토피 유사 피부질환 예방 및 치료용 약학조성물 또는 건강기능성 식품에 관한 것이다.