THE BROAD INSTITUTE, INC.;THE GENERAL HOSPITAL CORPORATION;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
HACOHEN, NIR,WU, CATHERINE J.,FRITSCH, EDWARD F.
申请号：
CA2908434
公开号：
CA2908434A1
申请日:
2014.04.07
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides a method of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia, which includes identifying a plurality of mutations in the neoplasia, analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof, and producing, based on the identified subset, a personalized neoplasia vaccine.
