[PROBLEMS] To provide a medicine storage cassette and a medicine dispensing device that can dispense medicine sheets one by one even when two medicine sheets stacked with the surfaces on which pocket portions are formed facing each other are accommodated. [Solution] A storage part (11) in which the PTP sheet (100) is stored, a payout part (2) for paying out the PTP sheet (100) from the storage part (11), and a storage part in the storage part (11). A moving operation part (3) for moving the PTP sheet (100) toward the payout part (2), and the payout part (2) is located above the bottom part of the storage part (11). A first stopper portion (21) that protrudes and hits the lower edge of the PTP sheet (100) and a second stopper portion (22) that hits the lateral edge of the PTP sheet (100) are provided. [Selection] Figure 3[課題]ポケット部が形成された面を向かい合わせて重ね合わされた2枚の薬剤シートが収容される場合でも、1枚ずつ薬剤シートを払い出せる薬剤収容カセットおよび薬剤払出装置を提供する。[解決手段]PTPシート(100)が収容される収容部(11)と、PTPシート(100)を上記収容部(11)から払い出す払出部(2)と、上記収容部(11)内のPTPシート(100)を上記払出部(2)に向けて移動させる移動動作部(3)と、を備えており、上記払出部(2)は、上記収容部(11)の底部よりも上方に突出して上記PTPシート(100)の下縁に当たる第1ストッパー部(21)と、上記PTPシート(100)の横縁に当たる第2ストッパー部(22)と、を備える。【選択図】図3