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NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS
专利权人:
GRUNENTHAL GMBH
发明人:
FRANK, ROBERT,BAHRENBERG, GREGOR,CHRISTOPH, THOMAS,SCHIENE, KLAUS,DE VRY, JEAN,SAUNDERS, DEREK,PRZEWOSNY, MICHAEL,SUNDERMANN, BERND,LEE, JEEWOO
申请号:
NZ58038108
公开号:
NZ580381A
申请日:
2008.04.15
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed are pyridine compounds of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: 2-(3,4-Diaminophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide, N-(2-Butoxy-6-tert-butylpyridin-3-ylmethyl)-2-(3,4-diamino-phenyl)-propionamide and N-( (6-tert -Butyl-2-( 4-methylpiperid in-1-yl)pyridin-3-yl)methyl)-2-(3,4-diaminophenyl)propanamide. Also disclosed is a process for preparing compounds of formula (I), a pharmaceutical composition comprising a compound of formula (I) and the use of a compounds of formula (I) in the manufacture of a medicament for the treatment and/or prophylaxis of any one or more of the disorders selected from the group consisting of pain, including pain selected from the group consisting of acute pain, chronic pain, neuropathic pain, and visceral pain arthralgia hyperalgesia allodynia causalgia and migraine.
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