HANSON GUNNAR J,RUDOLPH ALEXANDER CHARLES,CAI BAO ZHONG,ZHOU MING,WELLER DWIGHT D
申请号：
IN11199/DELNP/2012
公开号：
IN2012DN11199A
申请日:
2012.12.26
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
THE INVENTION CONCERNS AN OLIGOMER COMPRISING A BACKBONE THE BACKBONE COMPRISING A SEQUENCE OF MORPHOLINO RING STRUCTURES JOINED BY INTERSUBUNIT LINKAGES THE INTERSUBUNIT LINKAGES JOINING A 3 END OF ONE MORPHOLINO RING STRUCTURE TO A 5 END OF AN ADJACENT MORPHOLINO RING STRUCTURE WHEREIN EACH MORPHOLINO RING STRUCTURE IS BOUND TO A BASEPAIRING MOIETY SUCH THAT THE OLIGOMER CAN BIND IN A SEQUENCE SPECIFIC MANNER TO A TARGET NUCLEIC ACID. THE DISCLOSED COMPOUNDS ARE USEFUL FOR THE TREATMENT OF DISEASES WHERE INHIBITION OF PROTEIN EXPRESSION OR CORRECTION OF ABERRANT MRNA SPLICE PRODUCTS PRODUCES BENEFICIAL THERAPEUTIC EFFECTS.
