СЕЛА Йорам (IL),ЛИВНАХ Нурит (IL),ЛАМЕНСДОРФ Ицхак (IL),МАДМОН Томер (IL)
申请号：
RU2012136723/15
公开号：
RU2012136723A
申请日:
2011.02.03
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an active agent comprising a propargylamine moiety aminoindanovy fragment and / or propargylamine, aminoindanovy and fragments thereof or a pharmaceutically acceptable salt thereof, prepared in a form for prolonged release of said active agenta.2. A pharmaceutical composition according to claim 1, characterized in that said active agent is a N-propargyl-1-aminoindan, an enantiomer thereof, a metabolite thereof, an analog thereof or a pharmaceutically acceptable sol.3. A pharmaceutical composition according to claim 2, characterized in that said active agent is R (+) - N-propargyl-1-aminoindan (rasagiline), S - (-) - N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof .4. A pharmaceutical composition according to claim 3, characterized in that said pharmaceutically acceptable salt is selected from the mesylate salt ezilatnoy salt, tosylate salt, sulfate salt, sulfonate salts, phosphate salts, carboxylate salts, maleate salts, fumarate salts, tartrate salts, benzoate salts, acetate salt, hydrochloride salt or the hydrobromide salt of either R (+) - N-propargyl-1-aminoindan or the S - (-) - N-propargyl-1-aminoindan, preferably the mesylate salt of R (+) - N-propargyl-1 -aminoindana.5. A pharmaceutical composition according to claim 2, characterized in that said metabolite N-propargyl-1-aminoindan is 1-aminoindan or a pharmaceutically acceptable sol.6. A pharmaceutical composition according to claim 2, characterized in that said analogue of N-propargyl-1-aminoindan is 4-fluoro-N-propargyl-1-aminoindan, 5-fluoro-N-propargyl-1-aminoindan, 6-fluoro- N-propargyl
