Douglas Charles Hanson,Mark Joseph Neveu,Eileen Elliott Mueller,Jeffrey Herbert Hanke,Steven Christopher Gilman,C. Geoffrey Davis,Jose Ramon Corvalan
申请号：
US13399448
公开号：
US20120148597A1
申请日:
2012.02.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
