VORBRUEGGEN, HELMUT,Vorbrüggen, Helmut, 13507, Berlin, DE
申请号：
DE102010027595
公开号：
DE102010027595A1
申请日:
2010.07.23
申请国别(地区):
DE
年份:
2012
代理人:
摘要：
Die klinische Applikation von Adenosin-Derivaten der allgemeinen Formel 2 insbesondere aber von 1 zur Senkung der Körpertemperatur bei drohender Ischämie der Gehirngefäße, wie sie bei Herzanfällen und Schlaganfällen, nach Unfällen (Badeunfällen) und auch bei länger andauernden chirurgischen Eingriffen wie bei Herzoperationen auftreten kann.Clinical application of adenosine derivative (II), preferably (5R)-2-(6-{[2-(3,4-dihydroxyphenyl)ethyl]amino}-9H-purin-9-yl)-5-(hyd roxymethyl)oxolane-3,4-diol, for reducing body temperature during impending ischemia of brain vessels, which occur during heart attacks and strokes after accidents, preferably drowning accidents and during prolonged surgical interventions, preferably cardiac operations, is claimed. Clinical application of adenosine derivative of formula (II), preferably (5R)-2-(6-{[2-(3,4-dihydroxyphenyl)ethyl]amino}-9H-purin-9 -yl)-5-(hydroxymethyl)oxolane-3,4-diol, for reducing body temperature during impending ischemia of brain vessels, which occur during heart attacks and strokes after accidents, preferably drowning accidents and during prolonged surgical interventions, preferably cardiac operations, is claimed. R1 : H, NH 2or OH and R2 : CH 2OH, CH 2OR 3, CH 2PO(OH) 2, CH 2OPO(OH)OX, CH 2POO(OH)O ->HNR 3 +> X : Na, K, Li, N(R3)4 or lysine R3 : Me, Et, (CH 2) 2OH or O(CH 2) 2O(CH 2) 2OH, and R4 : H, acetyl, OCOEt or COC 17H 35. [Image] - ACTIVITY : Antipyretic. No biological data given. - MECHANISM OF ACTION : None given.
