PROBLEM TO BE SOLVED: To provide an anti-IL-36R binding compound, particularly a novel anti-IL-36R antibody, and a therapeutic method, a diagnostic method and a composition using the same. A bind with the following K D 0.1 nM human IL-36R, anti-IL-36R antibody or antigen-binding fragment thereof. [Selection diagram] None【課題】抗IL-36R結合化合物、特に、新規抗IL-36R抗体、及びそれを用いた治療方法及び診断方法並びに組成物の提供。【解決手段】ヒトIL-36Rに0.1nM以下のKDで結合する、抗IL-36R抗体又はその抗原結合フラグメント。【選択図】なし