The Drug Wu System Elixirs and its Men System Prepare method of 3- (4- cinnamyl -1- piperazinyl) aminoderivative comprising 3- formoxyl Rifamycin Sodium and 3- formoxyl rifamycin-S农业专利-农业专业知识服务系统

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The Drug Wu System Elixirs and its Men System Prepare method of 3- (4- cinnamyl -1- piperazinyl) aminoderivative comprising 3- formoxyl Rifamycin Sodium and 3- formoxyl rifamycin-S

专利权人:: 阿迪帕姆單人股份公司;里伊博米尔．博治达诺夫．夫杜鲁夫;基里尔．阿瑟诺夫．尼诺夫;APOSTOLOVA-DIMOVA, VELICHKA ILIEVA;ADIPHARM EAD;基里爾．阿瑟諾夫．尼諾夫;里伊博米爾．博治達諾夫．夫杜魯夫;阿迪帕姆单人股份公司;FUDULOV, LYIBOMIR BOZHIDAROV;衛;NINOV, KIRIL ASENOV;卫理士卡．里列瓦．阿波斯托洛娃-迪莫瓦

发明人:: R．G．康斯坦丁诺瓦,R．G．康斯坦丁諾瓦,基里尔．阿瑟诺夫．尼诺夫,基里爾．阿瑟諾夫．尼諾夫,卫理士卡．里列瓦．阿波斯托洛娃迪莫瓦,衛理士卡．里列瓦．阿波斯托洛娃迪莫瓦,伊夫提米亚．伊万诺瓦．斯戴凡诺瓦,伊夫提米亞．伊萬諾瓦．斯戴凡諾瓦,罗森．克鲁莫夫．科伊特切夫,羅森．克魯莫夫．科伊特切夫,R.G.康斯坦丁诺瓦,R.G.康斯坦丁諾瓦,基里尔.阿瑟诺夫.尼诺夫,基里爾.阿瑟諾夫.尼諾夫,卫理士卡.里列瓦.阿波斯托洛娃迪莫瓦,衛理士卡.里列瓦.阿波斯托洛娃迪莫瓦,伊夫提米亚.伊万诺瓦.斯戴凡诺瓦,伊夫提米亞.伊萬諾瓦.斯戴凡諾瓦,罗森.克鲁莫夫.科伊特切夫,羅森.克魯莫夫.科伊特切夫

申请号：: MOJ003047

公开号：: MOJ003047B

申请日:: 2018.04.16

申请国别(地区):: MO

年份:: 2018

代理人:

摘要：: The bright She of this Hair Ji System Prepare includes to receive the method for System Elixirs as Ke on 3- (4- cinnamyl -1- piperazinyl)-aminoderivative Drug Learn of the mould base rifamycin-S of 3- formoxyl Rifamycin Sodium and 3- first of Huo Wu Quality,The System Elixirs that can receive on the Drug Learn has Needles Right leather LanShi Yang and removes from office the high activity of LanShi Overcast microorganism and Needles Right Knot core mycobacteria (tuberculous micobacteria) (including atypical and rifamycin resistance),And and be related to Yong Yu System Prepare 3- formoxyl Rifamycin Sodium and 3- formoxyl rifamycin-S 3- (4- cinnamyl -1- piperazinyl)-aminoderivative method. The method that Yong Yu System Prepare Drug Wu Group closes object is easy Ke Hang And and does not need to Ding Let Prepare with the Te that its Real is applied. The characteristic of the method for the compound described in what System Prepare is in high yield and Pure degree, to make molten Elixirs-second alcohol and water with the clear Jie in the border Ring in the System Prepare and dividing in From of object Quality, and No has Disabled to stay the molten Elixirs of Machine in Final product.本發明涉及製備包含作爲活性物質的3‑甲酰基利福霉素SV和3‑甲霉基利福霉素S的3‑(4‑肉桂基‑1‑哌嗪基)‑氨基衍生物的藥學上可接受的製劑的方法，所述藥學上可接受的製劑具有針對革蘭氏陽性和革蘭氏陰性微生物以及針對結核分枝杆菌(tuberculous micobacteria)（包括非典型的和利福霉素抗性的）的高活性，並且涉及用於製備3‑甲酰基利福霉素SV和3‑甲酰基利福霉素S的3‑(4‑肉桂基‑1‑哌嗪基)‑氨基衍生物的方法。用於製備藥物組合物的方法容易可行並且不需要用於其實施的特定設備。用於製備所述化合物的方法的特徵是高收率和純度，在物質的製備和分離中使用環境清潔的溶劑‑乙醇和水，以及在終産物中沒有殘留有機溶劑。