ARTMAN III, GERALD DAVID,POWERS, JAMES J,JI, NAN,ELLIOTT, JASON MATTHEW,MEREDITH, ERIK,LIU, DONGLEI,MA, FUPENG,MAINOLFI, NELLO,RAO, CHANG,MIRANDA, KARL
申请号：
NZ59303009
公开号：
NZ593030A
申请日:
2009.12.07
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
593030 Disclosed is a amide and pyrimidine substituted indole of formula (III) where the substituents are as disclosed in the specification. An example of a compound of formula (III) is N-(5-cyclopropyl-1-ethyl-1H-pyrazol-3-yl)-5-(2-( (methylamino)methyl)pyrimidin-4-yloxy)-1H-indole-1-carboxamide. Also disclosed are pharmaceutical combinations comprising a compound of formula (III) the use of a compound of formula (III) in the manufacture of a medicament and a method of treating a VEGF-R mediated disease in a non-human animal by administering a compound of formula (III).
