REIM, STEFAN,PHILIPP, ERIK,FUNK, FELIX,MULLER, HANS-MARTIN,GEISSER, PETER
申请号：
NZ58148708
公开号：
NZ581487A
申请日:
2008.05.21
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a water-soluble iron-carbohydrate derivative complex obtained from an aqueous iron(llI) salt solution and an aqueous solution of the product of the oxidation and subsequent derivatisation of one or more maltodextrins, wherein the oxidation is carried out with an aqueous hypochlorite solution at a pH value in the alkaline range, wherein one maltodextrin is used its destrose equivalent is from 5 to 20 and when a mixture of a plurality of maltodextrins is used the dextrose equivalent of the mixture is from 5 to 20 and the dextrose equivalent of the individual maltodextrins in the mixture is from 2 to 40, and the subsequent derivatisation is carried out with a suitable reagent. Further disclosed is a process for the preparation of an iron-carbohydrate complex as defined above, and wherein the derivatisation of the oxidised maltodextrin is carried out by one of the following processes: a) esterification with organic or inorganic acids or derivatives thereof, b) oxidation, c) carboxylalkylation, d) etherification, e) amidation, f) carbamate formation or g) anhydride formation. Further disclosed is a medicament which comprises an aqueous solution of an iron-carbohydrate derivative complex as defined above for the treatment or prophylaxis of iron deficiency states or anaemias.
