한국인스팜(주);한국인스팜(주);재단법인 전남생물산업진흥원;재단법인 전남생물산업진흥원;경희대학교 산학협력단;경희대학교 산학협력단; LTD.;KOREA INS PHARM CO.
发明人:
이정민,김용재,전우진,김선오,황권택,이유현,백흠영,이기행,유선아,김옥경,남다은,LEE, JEONG MINKR,KIM, YONG JAEKR,JUN, WOO JINKR,KIM, SUN OHKR,HWANG, KWON TACKKR,LEE, YOO HYUNKR,BAEK, HUM YOUNGKR,LEE, GI HEANGKR,YOO, SEON AKR,KIM, OK KYUNGKR
申请号：
KR1020130115997
公开号：
KR1020150036937A
申请日:
2013.09.30
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
According to the present invention, it is verified that a Curcuma longa L. extract has not caused particular change in body weight and various organ weights in an experiment about change in body weight, various organs, etc. on a C57BL/6 mouse in which immunodeficiency is induced (experimental example 1)； the Curcuma longa L. extract has effectively inhibited expression of cytokines such as IL-2, IL-4, IL-6, IL-10, IL-12, IL-15, TNF-alpha, IFN-gamma, etc. in a cytokine expression experiment of splenocytes (experimental example 2)； the Curcuma longa L. extract has increased T cell proliferation ability and B cell proliferation ability in an experiment about an effect on proliferation abilities of T/B cells in splenocytes (experimental example 3)； the Curcuma longa L. extract has reduced the amount of antigen-specific antibodies in the blood in an experiment about an effect on the amount of antigen-specific antibodies (IgG, IgE, IgA) in the blood (experimental example 3)； and the Curcuma longa L. extract has increased the activity of natural killer (NK) cells in an experiment about an effect on activation of NK cells in splenocytes (experimental example 4). Accordingly, the Curcuma longa L. extract can be practically used for a medicine and a health food which have an excellent immunity-enhancing effect and are excellent in prevention, inhibition and treatment of an immune deficiency syndrome caused by immune deterioration and damaged immune system. A pharmaceutical composition comprising a Curcuma longa L. extract for immune enhancement comprises the Curcuma longa L. extract in a content of 0.001-50 wt% with respect to the total weight of the composition.본 발명은 울금 추출물이 면역결핍 유도된 C57BL/6 마우스에서의 체중, 각종 장기 등에 대한 변화실험에서 별다른 체중 및 각종 장기 무게상의 변화가 없었으며(실험예 1), 비장세포(splenocyte)의 사이토카인 발현실험에서 IL-2, -4, -6, -10, -12, -15, TNF-α, IFN-γ 등의 사이토카인 발현을 효과적으로 억제하였고(실험예 2)； 비장세포에서의 T/B 세포의 증식능에 미치는 영향실험에서 T 세포 증식능 및 B 세포 증식능을 증가시켰고(실험예 3)； 혈중 항원 특이 항체 (IgG, IgE, IgA)양에 미치는 영향실험에서 혈중 항원 특
