Substitued sulphonamides having the general formula (I) and salts, hydrates and solvates thereof were prepared and described, wherein R1 is CO or SO2 and R2 is NH or O and where R represents linear or cyclic aliphatic chain and nrepresents number of linking aliphatic chain carbons (n can be 0, 1, 2 or 3), which are useful in the manufacture of the medicaments due to the carboanhydrase inhibition. These compounds are prepared by nucleophilic reaction of an amine with 4-sulfamoylbenzenesulphonyl chloride in the presence of triethylamine excess in tetrahydrofurane or in ether at temperature 0 to 20℃. The compounds show an antiglaucomatic activity.製備及說明具有通式(I)之經取代磺醯胺及其鹽、水合物及溶劑合物,其中R1為CO或SO2及R2為NH或O,以及其中R代表直鏈或環狀脂族鏈且n代表鍵結之脂族鏈之碳數(n可為0、1、2或3),此等化合物由於抑制碳酸酐酶,所以在製造藥劑上有用。此等化合物藉由於存在過多的三乙基胺下,在四氫呋喃或醚中且於0至20℃之溫度,使胺與4-磺醯基苯磺醯氯進行親核反應而製備。此等化合物顯示抗青光眼活性。