The present invention relates generally to a compound of formula (la):(see formula Ia)or a pharmaceutically acceptable salt thereof, wherein R11 is C1-8 alkyl, C2-8alkenyl,C3-14 cycloalkyl, a C6-14 aryl group, a 5-14 membered heteroaryl group, a 3-14memberedcycloheteroalkyl group, C1-8 alkoxy, halo, NR13R14, C(O)OR13, C(O)NR13R14, C1-8haloalkyl,formyl, carbalkoxy, C1-8alkylOH, C(O)R13, SO2R13, C(O)NHC1-8alkylR13, NR13R14,SO2NR13R14, OCF3, NHC(O)R13, CH2OC(O)NR13R14, CH2NR13R14, NHC(O)OR13,NHC(O)NR13R14, CH2NHSO2R13, CH2NHC(O)OR13, OC(O)R13, or NHC(O)R13； R12 is H,C1-8 alkyl, a C6-14 aryl group, C1-8 haloalkyl, C1-8 alkoxy, halo, NH2, CN,OCF3, OH,C(O)NR13R14, C(O)R13, NR13R14, NHC(O)R13, SO2R13, or SO2NR13R14； and R13 andR14are independently H, C1-8 alkyl, C2-8 alkenyl, C3-14 cycloalkyl, a C6-14 arylgroup, a 5-14 memberedheteroaryl group, a 3-14 membered cycloheteroalkyl group, C1-8haloalkyl, C1-8alkylOH, orC1-8alkoxy. Such compounds may be used for the diagnosis and treatment ofpathologiesrelating to the Hedgehog pathway, including but not limited to tumorformation, cancer,neoplasia, and non-malignant hyperproliferative disorders.
