H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE; INC.
发明人:
ALAN F. LIST,SHENG WEI
申请号：
US15522955
公开号：
US20170335009A1
申请日:
2015.10.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are compositions and methods for targeted treatment of TLR9-expressing cancers, such as primary human MDS progenitors and hematopoietic stem cell (HSC), as well as lung and breast cancers. In particular, multispecific, multivalent antibodies are disclosed that are able to engage T-cells to destroy TLR9-expressing malignant cells.
