Bryan L. Spangelo,Van Vo,Pradip K. Bhowmik,Ontida Tanthmanatham,Haesook Han
申请号：
US13404257
公开号：
US08703756B2
申请日:
2012.02.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method of reducing the in vivo viability of cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells has steps of:a) identifying a prospective patient having cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells andb) administering a cisplatin derivative to the prospective patient so that the cisplatin derivative will contact the cancer cellswherein the cisplatin derivative is a 4,4′-bis[RO]-2,2′-bipyridine)PtCl2 where, R is selected from the group consisting of —(CH2)nCH3 where n=2, 3, 4 or 5, and —(CH2)n[O(CH2)m]yO(CH2)zCH3 where n=2, m=2, y=2, z=1. A novel synthetic process for the manufacture of these compounds (and their analogs) is also provided.
