Tin-Yun Ho;Chien-Yun Hsiang;Shih-Lu Wu;Ji-An Liang;Chia-Cheng Li;Hsin-Yi Lo
发明人:
Tin-Yun Ho,Chien-Yun Hsiang,Shih-Lu Wu,Ji-An Liang,Chia-Cheng Li,Hsin-Yi Lo
申请号：
US12901096
公开号：
US20120027676A1
申请日:
2010.10.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A modified sodium iodide symporter (NIS) protein is provided. The modified NIS protein comprises an amino acid sequence of SEQ ID NO.1 with the proviso that at least one amino acid residue within SEQ ID NO. 1 is changed. The modified NIS protein has an enhanced transport function, and the expression of the modified NIS protein in the cells results in higher intracellular levels of a substrate of a NIS protein than does the expression of the same amount of a wild-type NIS protein.
