The present invention concerns methods for treating and preventing endothelial dysfunction and related disorders, including, for example, pulmonary arterial hypertension, using bardoxolone methyl or analogs thereof.本發明係關於使用齊墩果酸或其類似物治療和預防內皮功能障礙及相關病症(包括例如肺動脈高血壓)之方法。