Monovalent, bivalent and trivalent anti human respiratory syncytial virus (HRSV) nanobody constructs for the prevention and/or treatment of respiratory tract infections
Erik Depla;Catelijne Stortelers;Stephanie Staelens
发明人:
Erik Depla,Catelijne Stortelers,Stephanie Staelens
申请号：
US13375357
公开号：
US08945567B2
申请日:
2010.06.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.
