SON, HOE JOO,손회주,BANG, SUNG HUN,방성훈,KWON, HYEOK BEOM,권혁범,YOON, IK HWAN,윤익환,CHOI, MIN SIK,최민식,YANG, JI EUN,양지은,SON, HOE JOOKR,BANG, SUNG HUNKR,KWON, HYEOK BEOMKR,YOON, IK HWANKR,CHOI, MIN SIKKR,YANG, JI EUNKR
申请号：
KR1020140094029
公开号：
KR1020160013326A
申请日:
2014.07.24
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a manufacturing method of silodosin and a novel intermediate product thereof. More particularly, the manufacturing method in the present invention uses a novel intermediate product to manufacture high-yield and high-purity silodosin through a simple manufacturing process. Therefore, the manufacturing method in the present invention is industrially useful. The manufacturing method of the present invention comprises the steps of: a) preparing a compound represented by chemical formula 4 by desalinating a compound represented by chemical formula 5 in presence of alkaline metal hydroxide； b) preparing a compound represented by chemical formula 2 by hydrolyzing the compound represented by chemical formula 4 using alkaline metal hydroxide in presence of an oxidizing agent； c) preparing a compound represented by chemical formula 1 by making a coupling reaction of the compounds represented by chemical formula 2 and chemical formula 3 in presence of an inorganic base； and d) dissolving the compound represented by chemical formula 1 in an alcohol at an elevated temperature and precipitating crystals after seeding &gamma；-type crystals of silodosin.본 발명은 실로도신 및 그의 중간체의 제조방법에 관한 것으로, 더욱 상세하게는 신규 중간체를 사용하여 단순한 제조공정을 통해 고수율 및 고순도의 실로도신을 제조할 수 있어 산업적으로 매우 적합한 제조방법을 제공한다. 색인어실로도신, 인돌린 화합물,
