LIPSON, DORON,STEPHENS, PHILIP JAMES,PARKER, ALEXANDER N.,DOWNING, SEAN R.,HAWRYLUK, MATTHEW J.
申请号：
CA2846197
公开号：
CA2846197A1
申请日:
2012.08.23
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least ex on 12 of RET or a fragment thereof (e.g., exons 12-20 5 of RET or a fragment thereof).
