Wu, Herren,DallAcqua, William,Damschroder, Melissa,Casas-Finet, Jose
申请号：
AU2011221380
公开号：
AU2011221380B2
申请日:
2011.09.07
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2011221380B220131017.pdf#####ABSTRACT The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the 5 binding of Fc to one or more Fc ligand (e.g., Fc&gammadRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc&gammadR and/or CIq. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the 10 application of said Fc variants particularly for therapeutic purposes. 15
