Hiroaki Yanagisawa,Yasuo Shimoji,Koichi Fujimoto,Takuro Kanazaki,Yoshiya Anemiya,Hiroyuki Koike,Toshio Sada
申请号：
DE69231798
公开号：
DE69231798T3
申请日:
1992.02.21
申请国别(地区):
DE
年份:
2012
代理人:
摘要：
Compounds of formula (I):(see fig. I)wherein R1 is alkyl or alkenyl R2 and R3 arehydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, oraryl fused to cycloalkyl R4 is hydrogen, alkyl,alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl,totrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyltetrahydrofuryl, a group of formula-SiR a R b R c, in which R a, R b and R c are alkylor aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl,aralkyl, aryl or alkanoyloxymethoxycarhonylR5 is carboxy or a group of formula -CONR8R9,wherein R8 and R9 are hydrogen atoms or alkyl, orR8 and R9 together form alkylene R6 is hydrogen,alkyl, alkoxy or halogen R7 is carboxy ortetrazol-5-yl and pharmaceutically acceptable salts andesters thereof have hypotensive activity and can be usedfor the treatment and prophylaxis of hypertension. Theymay be prepared, inter alia, by reacting abiphenylmethyl compound with an imidazole compound.
