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Dry powder inhalation drug product exhibiting moisture control characteristics and method of administration thereof
专利权人:
グラクソ グループ リミテッド
发明人:
アスワニア,オサマ,ジァン,チョン,ロシュ,トレヴァー,チャールズ,ウィタカー,マーク,アスワニア,オサマ,ジァン,チョン,ロシュ,トレヴァー,チャールズ,ウィタカー,マーク
申请号:
JP2015038300
公开号:
JP6091537B2
申请日:
2015.02.27
申请国别(地区):
JP
年份:
2017
代理人:
摘要:
A drug product comprising: a dry powder inhalation device containing one or more pharmaceutical compositions present therein, wherein the one or more pharmaceutical compositions comprise active ingredients (I) 4-{(1 R )-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol, or a salt thereof, and (II) (6±,11ß,16±,17±)-6,9-difluoro-17-{[(fluoromethyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2- furancarboxylate or a solvate thereof; a hygroscopic material; and a package which encompasses the dry powder inhalation device and the hygroscopic material defining an enclosed volume therein; wherein each of the active ingredients (I) and (II) are present in the same or different pharmaceutical compositions, and wherein the enclosed volume within the package exhibits a Relative Humidity of from 20% to 40%.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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