ELMORE, Steven,SOUERS, Andrew,WANG, Li Chun,GHAYUR, Tariq,PERPER, Stuart J.
申请号：
ES11793928
公开号：
ES2603129T3
申请日:
2011.11.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound that is: (a) 4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - ({ 3-nitro-4 - [(tetrahydro-2H-pyran-4-ylmethyl) amino] phenyl} sulfonyl) -2- (1H-pyrrolo [2,3-b] pyridin-5-yloxy) benzamide or one of its salts pharmaceutically acceptable, or (b) 4- (4 - {[2 - ('4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -N - [( 4 - {[(trans-4-hydroxy-4- methylcyclohexyl) methyl] amino) -3-nitrophenyl) sulfonyl] -2- (1 H -pyrrolo [2,3-b] pyridine-5-yloxy) benzamide or one of its pharmaceutically acceptable salts for use in the treatment of systemic lupus erythematosus, lupus nephritis or Sjögren's syndrome.Un compuesto que es: (a) 4-(4-{[2-(4-clorofenil)-4,4-dimetilciclohex-1-en-1-il]metil}piperazin-1-il)-N-({3-nitro-4-[(tetrahidro-2H-piran-4- ilmetil)amino]fenil} sulfonil)-2-(1H-pirrolo[2,3-b]piridin-5-iloxi)benzamida o una de sus sales farmacéuticamente aceptables, o (b) 4-(4-{[2-('4-clorofenil)-4,4-dimetilciclohex-1-en-1-il]metil}piperazin-1-il)-N-[(4-{[(trans-4-hidroxi-4- metilciclohexil)metil]amino)-3-nitrofenil)sulfonil]-2-(1H-pirrolo[2,3-b]piridin-5-iloxi)benzamida o una de sus sales farmacéuticamente aceptables para su uso en el tratamiento del lupus eritematoso sistémico, la nefritis por lupus o el síndrome de Sjögren.
