METHOD FOR THE DISCOVERY, VALIDATION AND CLINICAL APPLICATION OF MULTIPLEX BIOMARKER ALGORITHMS BASED ON OPTICAL, PHYSICAL AND/OR ELECTROMAGNETIC PATTERNS
A method for determining multiplex biomarker algorithms based on optical, physical and/or electromagnetic patterns, and applying the multiplex biomarker algorithms so as to provide a single diagnostic result indicative of a medical condition, the method comprising:measuring multiple physical, electromagnetic or optical patterns in the setting of experimentally induced or clinically occurring disease using at least one of physical, electromagnetic and optical sensorsusing known mathematical or machine learning algorithms to compile the measured parameters, or their signal transformed versions, into a uniplex scale or index using a clinical classifier, such that the uniplex scale or index has better clinical performance in identifying a medical condition than any of the input parameters individuallyoptimizing the algorithm iteratively using additional clinical data sets and inputting patient characteristics and laboratory derived measurementsusing the uniplex scale or index to identify a medical condition anddisplaying to a user the single diagnostic result indicative of a medical condition.
