5 0 5 10 50 n W O 20 171127 / 6 2 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/112762 Al 29 June 2017 (29.06.2017) WIPO I PCT 1111111111111101110111111111110101111101110111011101011111111011111111111110111111 Treatment in NSG mice with established Raji tumors Tum or Vo lume mm ( 3) 150 (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2016/068003 (22) International Filing Date: 21 December 2016 (21.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/270,749 22 December 2015 (22.12.2015) US 62/306,031 9 March 2016 (09.03.2016) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US] 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). (72) Inventor: BROWNSTEIN, Carrie c/o Regeneron Phar- maceuticals, Inc., 777 Old Saw Mill River Road, Tarry- town, New York 10591-6707 (US). (74) Agents: TERMES, Lance, A. et al. Schwabe, Williamson & Wyatt, 1211 SW 5th Avenue, Suite 1900, Portland, OR 97204 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST,
