DIMARCHI, RICHARD DENNIS,GLAESNER, WOLFGANG,MILLICAN, ROHN LEE JUNIOR,VICK, ANDREW MARK,ZHANG, LIANSHAN
申请号：
PL04722142
公开号：
PL1605897T3
申请日:
2004.03.19
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.
