A method comprising (a) obtaining young adult stem cells (YASC) from a first subject； (b) lysing the YASC to generate a lysate comprising an intracellular matrix (ICM) and other cellular components； (c) filtering the lysate through a filter having a membrane size of equal to or less than 0.4 micron to obtain a filtrate； and (d) applying the filtrate to a culture of aged adult stem cells (AASC) for a time period ranging from about 24 hours to about 30 days to generate a reprogrammed AASC (R-AASC) wherein the AASC were obtained from a second subject and wherein the R-AASC when infused into a breast cancer stem model results in a reduced number of breast cancer cells in bone marrow in comparison to a breast cancer stem model having AASC that have not been reprogrammed.
