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METHODS FOR TREATING INFLAMMATORY DISEASES OF THE COLUM
专利权人:
ПЛУРИСТЕМ ЛТД. (IL)
发明人:
МЕИРОН Моран (IL)
申请号:
RU2010153362/15
公开号:
RU2010153362A
申请日:
2009.05.26
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method for treating ulcerative colitis or Crohn’s disease in an individual in need thereof, the method comprising administering to said individual a therapeutically effective amount of adherent cells originating from the placenta or adipose tissue, resulting in the treatment of ulcerative colitis or Crohn’s disease. ! 2. The method of claim 1, wherein said adherent cells express one or more of CD73, CD90, CD29, or CD105. ! 3. The method of claim 1, wherein said adherent cells do not express CD3, CD4, CD45, CD80, HLA-DR, CD11b, CD14, CD19, CD34 or CD79. ! 4. The method of claim 1, wherein said adherent cells suppress an immune response by suppressing T-cell activity. ! 5. The method of claim 1, wherein said adherent cells are obtained from a three-dimensional (3D) culture. ! 6. The method according to claim 5, where the specified three-dimensional (3D) culture includes a 3D bioreactor. ! 7. The method according to claim 5, where the cultivation of these attached cells in the specified 3D culture is carried out using perfusion. ! 8. The method according to claim 5, where the cultivation of these attached cells is carried out for at least 3 days. ! 9. The method according to claim 1, where these adherent cells include cultured cells from the placenta or adipose tissue under conditions of 2-dimensional (2D) cultivation. ! 10. The method of claim 9, wherein at least 12% of said adherent cells are in the S and / or G2 / M phase of proliferation. ! 11. The method according to claim 1, wherein said adherent cells are less committed towards the osteogenic line of differentiation compared to adherent cells originating from the bone marrow when grown and allowed to differentiate under the same conditions. ! 12. The method according to claim 1, where indicated1. Способ лечения язвенного колита или болезни Крона у нуждающегося в этом индивидуума, где способ включает введение указанному индивидууму терапевтически эффективного количества прикрепляющихся клеток, происходящих и
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