MISSÃO SALESIANA DE MATO GROSSO UNIVERSIDADE CATÓLICA DOM BOSCO
发明人:
CRISTIANO MARCELO ESPINOLA CARVALHO,ELIZANGELA DE BARROS,LUCAS BIANCHI NUNES,LUDOVICO MIGLIOLO,MARCOS ANTONIO FERREIRA,OCTÁVIO LUIZ FRANCO,PATRICIA SOUZA E SILVA,SIMONE CAMARGO SANCHES
申请号：
BR102018011752
公开号：
BR102018011752A2
申请日:
2018.06.05
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
butylatus, synthetic peptides analogous with antimicrobial activity and anti tumor cells in culture refers to the construction of elaborated by rational design, and entitled butylatus-1 (kafkfifkfaaai-oh), butylatus-2 (kafrflrkfaaai-oh), butylatus-3 (klakfifklfaaaf -oh) and butylatus-4 (rlarfirrlfaaar-oh), which have direct activity against pathogenic microorganisms, escherichia coli and enterococcus faecalis, which can cause innumerable damage to health, especially to immunosuppressed patients, resulting in costly expenses for public and private health. the peptides, besides being efficient in the tests performed, do not have cytotoxic or hemolytic action, and can be applied in the development of drugs to control human infections, as well as in agribusiness to control phytopathogenic and pathogenic bacteria in animals, including their potential application in the area of cosmeceuticals for the prevention and treatment of unsightly skin changes of infections in the skin and in the pilosebaceous apparatus. the synthetic peptides presented here fall within the international patent classification in section a - human needs； subsection a61 - health, rescue, recreation, medical or veterinary science, hygiene； subsection a61 k 38/00 - medicinal preparations containing peptides. in section c - chemistry； subsection c07k - peptides； subsection 07k 1/00 - general processes for preparing peptides； as well as in subsection c12n 15/00 - mutation or genetic engineeringbutylatus, peptídeos sintéticos análogos com atividade antimicrobiana e anti células tumorais em cultura refere-se à construção de elaborados por desenho racional, e intitulados butylatus-1 (kafkfifkfaaai-oh), butylatus-2 (kafrflrkfaaai-oh), butylatus-3 (klakfifklfaaaf-oh) e butylatus-4 (rlarfirrlfaaar-oh), os quais possuem atividade direta contra microrganismos patogênicos, sendo eles, escherichia coli e enterococcus faecalis, que podem causar inúmeros danos à saúde, principalmente a pacientes imunossuprimidos, re
