Combination therapy comprising a superagonistic antibody against interleukin-2 and a checkpoint blockade agent

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专利权人:

Universität Zürich

发明人:

Boyman, Onur,Arenas-Ramirez, Natalia

申请号：

AU2017206618

公开号：

AU2017206618A1

申请日:

2017.01.11

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The invention relates to a combination medicament comprising a human interleukin-2 (hIL-2)-specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25, and an immune checkpoint inhibitor agent. The hIL-2 antibody can be given without or with recombinant hIL-2 and is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006 the binding to hIL-2 is characterized by a dissociation constant (K

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