BROWN, MARC BARRY,布朗 马克,布朗 馬克,STEVENSON, CAMERON ROBERT,史蒂芬森 卡麦隆,史蒂芬森 卡麥隆,EVANS, CHARLES RODNEY GREENAWAY,伊凡 查尔斯,伊凡 查爾斯,布朗 马克,布朗 馬克,史蒂芬森 卡麦隆,史蒂芬森 卡麥隆,伊凡 查尔斯,伊凡 查爾斯
申请号：
TW105117746
公开号：
TW201717942A
申请日:
2016.06.04
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.本發明描述用於局部投予猬(hedgehog)抑制劑化合物之組成物。於一實施態樣中，該猬抑制劑化合物為沛提德吉(patidegib)且該局部用組成物所包含之該化合物係在溶劑系統中，該溶劑系統包含一元伯醇(monohydric primary alcohol)和多元醇，其重量比為約0.9至1.8。於另一實施態樣中，該猬抑制劑為伊曲康唑(itraconazole)且該局部用組成物所包含之該化合物係在溶劑系統中，該溶劑系統包含一元伯醇和可選擇之低級烷基封端的寡聚型亞烷基二醇(其重量比為約0.8至2.6)與稠合之二環醚。本發明亦描述使用該組成物之方法，其中於一實施態樣中，該組成物係經局部施用以用於治療或預防基底細胞癌。
