A pharmaceutical composition comprising sorbic and benzoic acid and derivatives thereof which improves the activity of a neuropharmaceutical, and its use, pharmaceutical formulation and method of mitigating one or more symptoms of a neuropsychiatric disorder.
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HAR BOR-UCLA MEDICAL CENTER;LOS ANGELES BIOMED RES INST
发明人:
GUOCHUAN EMIL TSAI,TSAI GUOCHUAN EMIL
申请号：
BRPI1007173
公开号：
BRPI1007173A2
申请日:
2010.01.19
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder ( e . g ., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc .) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent ( e . g ., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc. ) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.
