A pharmaceutical composition for treating or ameliorating mucocutaneous, ocular toxicities, or side effects induced by blocking cellular growth and survival signal transduction pathways. The composition comprises an effective amount of a histone deacetylase inhibitor and a pharmaceutically acceptable carrier, salt or solvate thereof, wherein the cell growth and survival signal transduction pathways are blocked by an antibody targeted therapy agent, antibody fragment, targeted small-molecule chemical compound, low-molecular-weight tyrosine kinase inhibitor, peptide mimetic, anti-sense oligonucleotide (DNA and/or RNA), or ribozyme.本發明提供一種醫藥組成物及一藥學上可接受之載體,其可治療或減緩因細胞生長及存活之訊號傳遞途徑受到抑制而引起的黏膜/皮膚或眼睛毒性或副作用。本發明之組成物包括一有效量之組織蛋白去乙醯酵素抑制劑及其藥學上可接受之載體、鹽類或溶劑,且細胞生長及存活之訊號傳遞途徑係被一抗體標靶治療劑、抗體片段、小分子標靶化合物、低分子量酪胺酸抑制劑、擬態胜肽、反義寡核苷酸、或核醣酶所抑制。
