Alberto Baldi;Alejandro Gustavo Mladovan;Adrián Daniel Góngora
发明人:
Alberto Baldi,Adrián Daniel Góngora,Alejandro Gustavo Mladovan
申请号：
US14267504
公开号：
US09388239B2
申请日:
2014.05.01
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Murine and humanized anti-human VEGF antibodies and uses are disclosed. The anti-human VEGF antibodies of the invention have higher binding affinity for human VEGF-A, are stronger inhibitors of the VEGF-A induced proliferation of endothelial cells in culture as compared with anti-human VEGF antibodies in the art. Moreover, these antibodies cross react with human VEGF-B. The antibodies of the invention inhibit tumor growth in vivo in greater extent than Bevacizumab when administered at the same dosage.
