In some embodiments of the present disclosure, a method for manufacturing a polymeric medical balloon is provided which may include providing a mold, wherein the mold comprises a plurality of assembled parts configured for separation to remove a molded balloon, configuring the interior surface of a least a portion of at least one part of the mold with one or more micro-features, inserting a balloon preform within the mold, and expanding the preform within the mold to obtain an expanded balloon. The one or more micro-features of the mold produce one or more corresponding features on the surface of the expanded balloon, and the one or more corresponding features on the surface of the expanded balloon effect at least one of a depth and height between about 10 μm and about 500 μm such that the one or more corresponding features are configured as reference points for positional registration of the balloon for subsequent processing of the expanded balloon. The method may further include removing the expanded balloon from the mold.
