The instant invention is generally directed to a patient-friendly drug delivery system for targeted populations, such as pediatric and geriatric patients. Specifically, the present invention relates to a pharmaceutical composition in the form of mini-tablets. Even more specifically, the present invention relates to a pharmaceutical composition comprising a therapeutically-effective amount of melatonin in the form of mini-tablets.本發明概言之係關於用於諸如兒童及老年患者之目標群體之患者友好型藥物遞送系統。特定而言,本發明係關於呈小錠劑形式之醫藥組合物。甚至更特定而言,本發明係關於呈小錠劑形式之包含治療有效量之褪黑素之醫藥組合物。