KAWAMURA, RYOICHI,川村亮一,川村亮一,TORIKAI, MASAHARU,鸟饲正治,鳥飼正治,KAMAKURA, SATOSHI,鎌仓悟史,鎌倉悟史,IWAMOTO, SEISHI,岩本征士,岩本征士,SOEJIMA, KENJI,副岛见事,副島見事,MAKIZUMI, KEIICHI,牧角啓一,牧角啓一, NAKATAKE, HIROSHI,中武,中武,SASAKI, TAK
申请号：
TW106100830
公开号：
TW201729837A
申请日:
2017.01.11
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
A vaccine for human papilloma virus (HPV) infection for prevention or treatment of HPV infection is provided. A chimeric protein wherein HPVL2 peptide consisting of about 20 amino acid resides is inserted between position 142 and position 143 in the amino acid sequence of hepatitis B virus surface protein (HBs protein) a DNA fragment consisting of a nucleotide sequence coding for the amino acid sequence of said chimeric protein an expression vector wherein said DNA fragment is incorporated a chimeric protein-producing cell transformed with said expression vector and a vaccine for HPV infection comprising said chimeric protein as an active ingredient and a process for the preparation thereof.本發明提供用於預防或治療人類乳頭瘤病毒(HPV)感染症之HPV感染症用疫苗。在B型肝炎病毒表面蛋白質(HBs蛋白質)之胺基酸序列的142位與143位之間插有由約20個胺基酸所構成之HPVL2胜肽的嵌合蛋白質、由編碼該嵌合蛋白質之胺基酸序列之鹼基序列所構成的DNA片段、組入該DNA片段之表現載體、藉由該表現載體轉形而成之嵌合蛋白質產生細胞,以及以該嵌合蛋白質作為有效成分的HPV感染症用疫苗及其製造方法。由於本案的圖僅為實驗數據,並非本案的代表圖。故本案無指定代表圖。
