Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors

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专利权人:

SAMUMED LLC

发明人:

HOOD JOHN,KC SUNIL KUMAR

申请号：

NZ62248312

公开号：

NZ622483A

申请日:

2012.09.13

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are indazole-3-carboxamide derivative compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include 5-(Pyridin-3-yl)-N-(pyridin-4-yl)-1H-indazole-3-carboxamide and N-(6-carbamoylpyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide. The compounds are Wnt/&bgr-catenin signalling pathway inhibitors and may be useful in the treatment of various diseases associated with the aforementioned pathway including cancer.

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