SOON-SHIONG, PATRICK,RABIZADEH, SHAHROOZ,NIAZI, KAYVAN,BENZ, STEPHEN CHARLES
申请号：
CA3055958
公开号：
CA3055958A1
申请日:
2018.03.07
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Detection of under-expression of selected genes in NK cells is used to confirm a hypoxic tumor microenvironment that is ordinarily suppressive with respect to ADCC and cytotoxic cell killing of NK cells. Most notably, while hypoxia is known to upregulate HIF-1a and genes under the control of HIF-1a, hypoxia in a tumor microenvironment led to under-expression of selected genes, including HIF-1a. Thus, gene expression analysis of certain genes on NK cells can be used to detect conditions in a tumor that would indicate use of haNK cells.
