AN ADENOVIRUS VECTOR WHICH EXPRESSES REIC

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专利权人:

发明人:

KUMON, HIROMI,公文裕巳,公文裕巳,HUH, NAMHO,许南浩,許南浩,SAKAGUCHI, MASAKIYO,阪口政清,阪口政清,WATANABE, MASAMI,渡部昌实,渡部昌實

申请号：

TW101118828

公开号：

TW201303018A

申请日:

2012.05.25

申请国别(地区):

TW

年份:

2013

代理人:

摘要：

Provided is an adenovirus vector that expresses high levels of the REIC/Dkk-3 protein. The present invention is a DNA construct for the expression of REIC/Dkk-3 DNA, said construct being obtained by linking, from the 5 end: (i) a CMV promoter (ii) REIC/Dkk-3 DNA (iii) a polyadenylation sequence and (iv) an enhancer obtained by linking a telomerase reverse transcriptase (hTERT) enhancer, a SV40 enhancer, and a CMV enhancer, in that order.本發明提供一種高度表現REIC/Dkk-3蛋白質之腺病毒載體。一種用以使REIC/Dkk-3 DNA表現之DNA構建物,其自5末端側連接有(i)CMV啟動子;(ii)REIC/Dkk-3 DNA;(iii)polyA附加序列;以及(iv)以hTERT(Telomerase Reverse Transcriptase,端粒酶逆轉錄酶)促進子、SV40促進子及CMV促進子之順序連接而成之促進子。

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