Methods for treating cancer include administering and/or receiving, at a patient in need thereof, a therapeutic dose of an inhibitor of extracellular vesicle signaling. The methods can additionally include co-administering and/or additionally receiving, at the patient in need thereof, a therapeutic dose or regimen of chemotherapy. In some instances, the cancer includes solid tumor carcinomas such as, but not limited to, colorectal cancer, pancreatic cancer, breast cancer, lung cancer, and prostate cancer. The disclosed treatment methods can act to suppress one or more of tumor growth, resistance to drug therapy, evasion of apoptosis, and/or metastasis.
